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Skip to most important information Thanks for browsing nature.com. You might be using a browser Model with confined help for CSS. To obtain the top knowledge, we propose you use a more updated browser (or transform off compatibility mode in Internet Explorer).Mosaicism of unstable CAG repeats was confirmed in SCA2 brain and lymphoblasts mobile trac
Daughters et al. (2009) presented evidence which the expanded CTG repeat inside the ATXN8OS gene is transcribed into an mRNA having an expanded CUG repeat, conferring a harmful achieve of function that plays a job within the SCA8 phenotype. In brain tissue from humans and mice with SCA8, ATXN8OS mRNA that contains the expanded repeat was discovered
Daughters et al. (2009) offered proof the expanded CTG repeat in the ATXN8OS gene is transcribed into an mRNA by having an expanded CUG repeat, conferring a toxic get of perform that performs a job from the SCA8 phenotype. In Mind tissue from humans and mice with SCA8, ATXN8OS mRNA that contains the expanded repeat was discovered to build up as rib